648450 TrkA Inhibitor - CAS 388626-12-8 - Calbiochem

648450
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₅H₁₃N₃O₃S 388626-12-8

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648450-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewAn oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
      Catalogue Number648450
      Brand Family Calbiochem®
      References
      ReferencesWood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.
      Product Information
      CAS number388626-12-8
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₁₃N₃O₃S
      Chemical formulaC₁₅H₁₃N₃O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTrkA
      Primary Target IC<sub>50</sub>63 nM against TrkA
      Purity≥97% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TrkA Inhibitor - CAS 388626-12-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TrkA Inhibitor - CAS 388626-12-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      648450

      References

      Reference overview
      Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      DescriptionA potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number388626-12-8
      Chemical formulaC₁₅H₁₃N₃O₃S
      Structure formulaStructure formula
      Purity≥97% by HPLC (sum of two isomers)
      SolubilityDMSO (200 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.