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616404 Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem

616404
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Key Specifications Table

Empirical FormulaCAS #
C₂₂H₂₄N₆ • H₂O 1186649-59-1

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616404-1MG
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      Description
      Overview

      This product has been discontinued.



      A cell-permeable naphthyridine-cyclohexyl Tpl2 Kinase Inhibitor (Cat. No. 616373) analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 = 160 nM) with little activity (IC50 >20 µM) against EGFR, Src, MEK, p38, PKA, PKC, or S6. Reported to block LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 µM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).

      Catalogue Number616404
      Brand Family Calbiochem®
      Synonyms4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II
      References
      ReferencesKaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.
      Product Information
      CAS number1186649-59-1
      FormPale yellow solid
      Hill FormulaC₂₂H₂₄N₆ • H₂O
      Chemical formulaC₂₂H₂₄N₆ • H₂O
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      616404

      References

      Reference overview
      Kaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II
      DescriptionA cell-permeable naphthyridine-cyclohexyl Tpl2 Kinase Inhibitor (Cat. No. 616373) analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 = 160 nM) with little activity (IC50 >20 µM) against EGFR, Src, MEK, p38, PKA, PKC, or S6. Reported to block LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 µM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1186649-59-1
      Chemical formulaC₂₂H₂₄N₆ • H₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (1 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.