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612200 Tissue Plasminogen Activator, Human

612200
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Overview

Replacement Information

Key Specifications Table

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
612200-100UG
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      Plastic ampoule 100 μg
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      612200-1MG
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          Glass bottle 1 mg
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          Description
          OverviewNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration.
          Catalogue Number612200
          Brand Family Calbiochem®
          SynonymstPA
          References
          ReferencesKim, Y.H., et al. 1999. Science 284, 647.
          Tsirka, S.E., et al. 1995. Nature 377, 340.
          Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
          Product Information
          FormLyophilized
          FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥300 KU/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tissue Plasminogen Activator, Human SDS

          Title

          Safety Data Sheet (SDS) 

          Tissue Plasminogen Activator, Human Certificates of Analysis

          TitleLot Number
          612200

          References

          Reference overview
          Kim, Y.H., et al. 1999. Science 284, 647.
          Tsirka, S.E., et al. 1995. Nature 377, 340.
          Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-May-2011 JSW
          SynonymstPA
          DescriptionNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acid residues. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration. Dihydropyridine Ca2+ antagonist may increase levels of tPA.
          FormLyophilized
          FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
          SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Purity≥95% by SDS-PAGE
          Specific activity≥300 KU/mg protein
          SolubilityReconstitute with diH₂O to a final concentration of 1 mg/ml (e.g., 100 µg should be reconstituted in 100 µl).
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, Y.H., et al. 1999. Science 284, 647.
          Tsirka, S.E., et al. 1995. Nature 377, 340.
          Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.