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506236 Tiagabine Hydrochloride - CAS 145821-59-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine

Primary Target: GAT-1
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506236
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
145821-59-6C₂₀H₂₅NO₂S₂·HCl

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      		 Glass bottle 10 mg
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      Description
      OverviewA potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.
      Catalogue Number506236
      Brand Family Calbiochem®
      SynonymsGABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
      References
      ReferencesLaughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
      Hu, Q., et al. 1997. Brain Res. 753,260.
      Suzdak, P., et al., 1995. Epilepsia. 36, 612.
      Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.
      Product Information
      CAS number145821-59-6
      FormOff-white solid
      Hill FormulaC₂₀H₂₅NO₂S₂·HCl
      Chemical formulaC₂₀H₂₅NO₂S₂·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGAT-1
      Primary Target IC<sub>50</sub>67 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Tiagabine Hydrochloride - CAS 145821-59-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Laughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
      Hu, Q., et al. 1997. Brain Res. 753,260.
      Suzdak, P., et al., 1995. Epilepsia. 36, 612.
      Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      SynonymsGABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
      DescriptionA potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.
      FormOff-white solid
      CAS number145821-59-6
      Chemical formulaC₂₀H₂₅NO₂S₂·HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLaughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
      Hu, Q., et al. 1997. Brain Res. 753,260.
      Suzdak, P., et al., 1995. Epilepsia. 36, 612.
      Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.