Product Information
Applications
Biological Information
Primary TargetThyroid Hormone Receptor
Primary Target IC<sub>50</sub>1.5 µM as antagonist for thyroid hormone receptor (TR) in HeLa cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem Certificates of Analysis

TitleLot Number
609315

References

Reference overview
Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-December-2015 JSW
SynonymsTR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
DescriptionA cell-permeable, selective, high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Reported to block T3-L-triiodothyronine)-mediated interaction of TRα with nuclear receptor coactivator (NRC) and prevent stimulation of gene expression. Exhibits no antagonistic effects on retinoic acid receptor α (RARα) activity.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number251310-57-3
Chemical formulaC₂₁H₂₀F₃N₅O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSchapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Antagonists > Other Receptor Antagonists