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58346 Tetracycline, Hydrochloride - CAS 64-75-5 - Calbiochem

58346
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₂H₂₄N₂O₈ 64-75-5

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58346-10GM
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      Glass bottle 10 gm
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      58346-25GM
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          58346-50GM
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              Description
              OverviewBroad-based antibiotic agent that blocks protein synthesis by inhibiting binding of aminoacyl tRNA to the A-site of ribosomes. Induces cold shock-response and enhances P450 expression in bacteria.
              Catalogue Number58346
              Brand Family Calbiochem®
              References
              ReferencesKusano, K., et al. 1999. Arch. Biochem. Biophys. 367, 129.
              Lech, K. and Brent, R. 1995. In Current Protocols in Molecular Biology, Vol. 1 (Ausubel, F.M., et al. eds.) John Wiley & Sons, New York Unit 1.4.
              Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York, p. 1.6, A.6.
              Chopra, I. and Howe, T.G.B. 1978. Microbiol. Rev. 42, 707.
              Product Information
              CAS number64-75-5
              Activity≥900 µg/mg
              FormYellow crystalline solid
              Hill FormulaC₂₂H₂₄N₂O₈
              Chemical formulaC₂₂H₂₄N₂O₈
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Primary Targetbinding of aminoacyl tRNA to the A-site of ribosomes
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSQI9100000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +15°C to +30°C
              Protect from Light Protect from light
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for 1 month at -20°C. Agar plates are stable for 2 weeks at 4°C. Autoclaved media should be cooled to ≤55°C before adding tetracycline.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Tetracycline, Hydrochloride - CAS 64-75-5 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Tetracycline, Hydrochloride - CAS 64-75-5 - Calbiochem Certificates of Analysis

              TitleLot Number
              58346

              References

              Reference overview
              Kusano, K., et al. 1999. Arch. Biochem. Biophys. 367, 129.
              Lech, K. and Brent, R. 1995. In Current Protocols in Molecular Biology, Vol. 1 (Ausubel, F.M., et al. eds.) John Wiley & Sons, New York Unit 1.4.
              Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York, p. 1.6, A.6.
              Chopra, I. and Howe, T.G.B. 1978. Microbiol. Rev. 42, 707.

              Citations

              Title
            • Thomas S. Lendvay, et al. (2007) Compensatory paracrine mechanisms that define the urothelial response to injury in partial bladder outlet obstruction. American Journal of Physiology: Renal 293, F1147-F1156.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision13-September-2007 JSW
              DescriptionAn antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing binding of aminoacyl tRNA to the A-site and blocking translocation. Used commonly for selection of the bacterial tetr gene whose product, a 399-amino acid membrane-associated protein, functions in active export of the drug from the cell.
              FormYellow crystalline solid
              CAS number64-75-5
              RTECSQI9100000
              Chemical formulaC₂₂H₂₄N₂O₈
              Structure formulaStructure formula
              Activity≥900 µg/mg
              SolubilityEthanol (5 mg/ml) or H₂O (20 mg/ml)
              Storage +15°C to +30°C
              Protect from moisture
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for 1 month at -20°C. Agar plates are stable for 2 weeks at 4°C. Autoclaved media should be cooled to ≤55°C before adding tetracycline.
              Toxicity Standard Handling
              Merck USA index14, 9196
              ReferencesKusano, K., et al. 1999. Arch. Biochem. Biophys. 367, 129.
              Lech, K. and Brent, R. 1995. In Current Protocols in Molecular Biology, Vol. 1 (Ausubel, F.M., et al. eds.) John Wiley & Sons, New York Unit 1.4.
              Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York, p. 1.6, A.6.
              Chopra, I. and Howe, T.G.B. 1978. Microbiol. Rev. 42, 707.
              Citation
            • Thomas S. Lendvay, et al. (2007) Compensatory paracrine mechanisms that define the urothelial response to injury in partial bladder outlet obstruction. American Journal of Physiology: Renal 293, F1147-F1156.