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508839 Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem

508839
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₇NO₃ 321674-73-1

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      Description
      OverviewA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508839
      Brand Family Calbiochem®
      SynonymsBIBR 1532, BIBR-1532
      References
      ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
      Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
      Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
      Product Information
      CAS number321674-73-1
      FormOff-white solid
      Hill FormulaC₂₁H₁₇NO₃
      Chemical formulaC₂₁H₁₇NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTeomerase
      Primary Target IC<sub>50</sub>93 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Damm, K., et al. 2001. The. EMBO J. 20, 6958.
      Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
      Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2014 JSW
      SynonymsBIBR 1532, BIBR-1532
      DescriptionA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number321674-73-1
      Chemical formulaC₂₁H₁₇NO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
      Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
      Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.