Millipore Sigma Vibrant Logo

508839 Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem

A cell-permeable, selective, highly potent, non-nucleotide competitive inhibitor of telomerase activity (IC₅₀ = 93 nM in HeLa cells nuclear extracts).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BIBR 1532, BIBR-1532

Primary Target: Teomerase
View Products on Sigmaaldrich.com
508839
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
321674-73-1C₂₁H₁₇NO₃

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.08839.0001
Retrieving availability...
—
Limited Availability Limited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508839
      Brand Family Calbiochem®
      SynonymsBIBR 1532, BIBR-1532
      References
      ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
      Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
      Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
      Product Information
      CAS number321674-73-1
      FormOff-white solid
      Hill FormulaC₂₁H₁₇NO₃
      Chemical formulaC₂₁H₁₇NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTeomerase
      Primary Target IC<sub>50</sub>93 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      5.08839.0001 04055977261424

      Documentation

      Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Damm, K., et al. 2001. The. EMBO J. 20, 6958.
      Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
      Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2014 JSW
      SynonymsBIBR 1532, BIBR-1532
      DescriptionA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number321674-73-1
      Chemical formulaC₂₁H₁₇NO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
      Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
      Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.