532177 Tdp1 Inhibitor, CD00509 - Calbiochem

532177
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₉H₆N₂O₃S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5321770001
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          Glass bottle 25 mg
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          Description
          OverviewA cell permeable alkylidene barbiturate analog that acts as a potent and specific inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1; IC50 = 710 nM) and increases the number of g-H2AX foci in MCF-7 cells. Shown to sensitize MCF-7 cells to camptothecin (CPT), increase DNA breaks, and reduce cell proliferation. However, it does not affect the viability of normal mammary epithelial cells up to 10 µM levels. Synergistically reduces cell proliferation and induces apoptosis in MCF-7 cells when combined with Rucaparib, a PARP-1 inhibitor.
          Catalogue Number532177
          Brand Family Calbiochem®
          SynonymsTyrosyl-DNA phosphodiesterase 1 Inhibitor
          References
          ReferencesDean, R.A., et al. 2014. J. Biolmol. Screen. 19, 1372.
          Product Information
          FormYellow powder
          Hill FormulaC₉H₆N₂O₃S
          Chemical formulaC₉H₆N₂O₃S
          ReversibleY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetTdp1
          Primary Target IC<sub>50</sub>710 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tdp1 Inhibitor, CD00509 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Dean, R.A., et al. 2014. J. Biolmol. Screen. 19, 1372.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-January-2015 JSW
          SynonymsTyrosyl-DNA phosphodiesterase 1 Inhibitor
          DescriptionA cell permeable alkylidene barbiturate analog that acts as a potent and specific inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1; IC50 = 710 nM) and increases the number of g-H2AX foci in MCF-7 cells. Shown to sensitize MCF-7 cells to camptothecin (CPT), increase DNA breaks, and reduce cell proliferation. However, it does not affect the viability of normal mammary epithelial cells up to 10 µM levels. Synergistically reduces cell proliferation and induces apoptosis in MCF-7 cells when combined with Rucaparib, a PARP-1 inhibitor.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉H₆N₂O₃S
          Purity≥97% by HPLC
          SolubilityDMSO
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDean, R.A., et al. 2014. J. Biolmol. Screen. 19, 1372.