532177 Tdp1 Inhibitor, CD00509 - Calbiochem

532177
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₉H₆N₂O₃S

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      Glass bottle 25 mg
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      Description
      OverviewA cell permeable alkylidene barbiturate analog that acts as a potent and specific inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1; IC50 = 710 nM) and increases the number of g-H2AX foci in MCF-7 cells. Shown to sensitize MCF-7 cells to camptothecin (CPT), increase DNA breaks, and reduce cell proliferation. However, it does not affect the viability of normal mammary epithelial cells up to 10 µM levels. Synergistically reduces cell proliferation and induces apoptosis in MCF-7 cells when combined with Rucaparib, a PARP-1 inhibitor.
      Catalogue Number532177
      Brand Family Calbiochem®
      SynonymsTyrosyl-DNA phosphodiesterase 1 Inhibitor
      References
      ReferencesDean, R.A., et al. 2014. J. Biolmol. Screen. 19, 1372.
      Product Information
      FormYellow powder
      Hill FormulaC₉H₆N₂O₃S
      Chemical formulaC₉H₆N₂O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTdp1
      Primary Target IC<sub>50</sub>710 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Tdp1 Inhibitor, CD00509 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Dean, R.A., et al. 2014. J. Biolmol. Screen. 19, 1372.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-January-2015 JSW
      SynonymsTyrosyl-DNA phosphodiesterase 1 Inhibitor
      DescriptionA cell permeable alkylidene barbiturate analog that acts as a potent and specific inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1; IC50 = 710 nM) and increases the number of g-H2AX foci in MCF-7 cells. Shown to sensitize MCF-7 cells to camptothecin (CPT), increase DNA breaks, and reduce cell proliferation. However, it does not affect the viability of normal mammary epithelial cells up to 10 µM levels. Synergistically reduces cell proliferation and induces apoptosis in MCF-7 cells when combined with Rucaparib, a PARP-1 inhibitor.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₉H₆N₂O₃S
      Purity≥97% by HPLC
      SolubilityDMSO
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDean, R.A., et al. 2014. J. Biolmol. Screen. 19, 1372.