648493 TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem

648493
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₂H₂₂N₂O₃ 332382-54-4

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648493-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca2+ release (~10 µM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1 µM) with which it shows a synergistic effect. ML-SA1-induced Ca2+ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1 (Cat. No. 196000), a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells.
      Catalogue Number648493
      Brand Family Calbiochem®
      SynonymsMucolipin Synthetic Agonist 1, ML-SA1, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione
      References
      ReferencesShen, D., et al. 2012. Nat. Commun. 3, 731.
      Product Information
      CAS number332382-54-4
      FormOff-white powder
      Hill FormulaC₂₂H₂₂N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTRPML1,2,3
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      648493

      References

      Reference overview
      Shen, D., et al. 2012. Nat. Commun. 3, 731.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      SynonymsMucolipin Synthetic Agonist 1, ML-SA1, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione
      DescriptionA membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca2+ release (~10 µM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1 µM) with which it shows a synergistic effect. ML-SA1-induced Ca2+ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1 (Cat. No. 196000), a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number332382-54-4
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesShen, D., et al. 2012. Nat. Commun. 3, 731.