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616374 TRAIL, Human, Recombinant, E. coli

616374
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616374-100UG
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      Plastic ampoule 100 μg
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      Description
      OverviewRecombinant, human TRAIL (amino acids 114-281) expressed in E. coli. Ligand for TRAIL receptors DR4 and DR5. Displays potent antitumor activity against selected targets and induces apoptosis in a number of transformed cell lines, but not in normal tissues.
      Catalogue Number616374
      Brand Family Calbiochem®
      SynonymsApo2L, Human, Recombinant, E. coli, TNF-Related Apoptosis-Inducing Ligand, Human, Recombinant, E. coli
      References
      ReferencesLin, Y., et al. 2000. Mol. Cell. Biol. 20, 6638.
      Mitsaides, N., et al. 2000. Cancer Res. 60, 4122.
      Griffith, T.S., et al. 1999. J. Exp. Med. 189, 1343.
      Mariani, S.M., et al. 1997. J. Cell Biol. 137, 221.
      Pan, G., et al. 1997. Science 276, 111.
      Pan, G., et al. 1997. Science 277, 815.
      Sheridan, J.P., et al. 1997. Science 277, 818.
      Pitti, R.M., et al. 1996. J. Biol. Chem. 271, 12687.
      Wiley, S.R., et al. 1995. Immunity 3, 673.
      Product Information
      FormLiquid
      FormulationIn 500 mM NaCl, 10 mM Na₂HPO₄, 2.7 mM KCl, 2 mM KH₂PO₄, 0.1 mM DTT, ≤10% glycerol.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityInduces apoptosis in U937 cells at 1 μg/ml within 5 h.
      Purity≥95% by SDS-PAGE
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Contaminantsendotoxin <0.1 EU/µg TRAIL
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze
      (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TRAIL, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      TRAIL, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      616374

      References

      Reference overview
      Lin, Y., et al. 2000. Mol. Cell. Biol. 20, 6638.
      Mitsaides, N., et al. 2000. Cancer Res. 60, 4122.
      Griffith, T.S., et al. 1999. J. Exp. Med. 189, 1343.
      Mariani, S.M., et al. 1997. J. Cell Biol. 137, 221.
      Pan, G., et al. 1997. Science 276, 111.
      Pan, G., et al. 1997. Science 277, 815.
      Sheridan, J.P., et al. 1997. Science 277, 818.
      Pitti, R.M., et al. 1996. J. Biol. Chem. 271, 12687.
      Wiley, S.R., et al. 1995. Immunity 3, 673.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      SynonymsApo2L, Human, Recombinant, E. coli, TNF-Related Apoptosis-Inducing Ligand, Human, Recombinant, E. coli
      DescriptionRecombinant, human TRAIL (amino acids 114-281) expressed in E. coli. Ligand for TRAIL receptors DR4 and DR5. Displays potent antitumor activity against selected targets and induces apoptosis in a number of transformed cell lines, but not in normal tissues.
      FormLiquid
      FormulationIn 500 mM NaCl, 10 mM Na₂HPO₄, 2.7 mM KCl, 2 mM KH₂PO₄, 0.1 mM DTT, ≤10% glycerol.
      Concentration Label Please refer to vial label for lot-specific concentration
      Purity≥95% by SDS-PAGE
      Contaminantsendotoxin <0.1 EU/µg TRAIL
      Biological activityInduces apoptosis in U937 cells at 1 μg/ml within 5 h.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze
      (-70°C).
      Toxicity Standard Handling
      ReferencesLin, Y., et al. 2000. Mol. Cell. Biol. 20, 6638.
      Mitsaides, N., et al. 2000. Cancer Res. 60, 4122.
      Griffith, T.S., et al. 1999. J. Exp. Med. 189, 1343.
      Mariani, S.M., et al. 1997. J. Cell Biol. 137, 221.
      Pan, G., et al. 1997. Science 276, 111.
      Pan, G., et al. 1997. Science 277, 815.
      Sheridan, J.P., et al. 1997. Science 277, 818.
      Pitti, R.M., et al. 1996. J. Biol. Chem. 271, 12687.
      Wiley, S.R., et al. 1995. Immunity 3, 673.