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654270 TNP-470 - CAS 129298-91-5 - Calbiochem

654270
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Key Specifications Table

Empirical FormulaCAS #
C₁₉H₂₈CINO₆ 129298-91-5

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654270-10MG
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      Description
      OverviewA cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1 nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2 to 100 mg/kg in mice and rats; s.c.).
      Catalogue Number654270
      Brand Family Calbiochem®
      SynonymsAGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470
      References
      ReferencesZhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427.
      Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099.
      Yamaoka, M., et al. 1993. Cancer Res. 53, 4262.
      Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
      Ingber, D., et al. 1990. Nature 348, 555.
      Product Information
      CAS number129298-91-5
      FormWhite to light yellow solid
      Hill FormulaC₁₉H₂₈CINO₆
      Chemical formulaC₁₉H₂₈CINO₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationTNP-470, CAS 129298-91-5, is a cell-permeable Fumagillin (Cat. No. 344845) analog that specifically inhibits MetAP2 methionine aminopeptidase activity (IC50 = 1 nM for human MetAP2).
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TNP-470 - CAS 129298-91-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TNP-470 - CAS 129298-91-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      654270

      References

      Reference overview
      Zhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427.
      Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099.
      Yamaoka, M., et al. 1993. Cancer Res. 53, 4262.
      Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
      Ingber, D., et al. 1990. Nature 348, 555.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-September-2013 JSW
      SynonymsAGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470
      DescriptionA cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1 nM against human MetAP2) by covalently modifying MetAP2 active site histidine (aa 231 in human/mouse/rat; aa 174 in yeast) via its epoxide group, without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. Cellular MetAP2 inhibition is particularly effective in inducing endothelial cytostasis (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC proliferation by TNP-470), making TNP-470 a potent anti-angiogenesis agent in vivo (2 to 100 mg/kg in mice and rats; s.c.). Reported to be more potent and less toxic than Fumagillin.
      FormWhite to light yellow solid
      CAS number129298-91-5
      Chemical formulaC₁₉H₂₈CINO₆
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesZhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427.
      Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099.
      Yamaoka, M., et al. 1993. Cancer Res. 53, 4262.
      Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
      Ingber, D., et al. 1990. Nature 348, 555.