654256 TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

654256
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O 1049741-03-8

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654256-5MG
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      Description
      OverviewA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
      Catalogue Number654256
      Brand Family Calbiochem®
      Synonyms6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor
      References
      ReferencesHe, M.M., et al. 2005. Science 310, 1022.
      Product Information
      CAS number1049741-03-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
      Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α
      Primary Target IC<sub>50</sub>22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      654256

      References

      Reference overview
      He, M.M., et al. 2005. Science 310, 1022.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor
      DescriptionA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1049741-03-8
      Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHe, M.M., et al. 2005. Science 310, 1022.