530961 TAZ Activator, IBS008738 - Calbiochem

TAZ Activator, IBS008738 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone, Transcriptional Co-activator with PDZ-binding Motif (TAZ) Activator, WWTR1 Activator

530961
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₂₂N₄O₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.30961.0001
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          		 Glass bottle 5 mg
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          Description
          OverviewA benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number530961
          Brand Family Calbiochem®
          Synonyms(4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone, Transcriptional Co-activator with PDZ-binding Motif (TAZ) Activator, WWTR1 Activator
          References
          ReferencesYang, Z., et al. 2014. Mol. Cell. Biol. 34, 1607.
          Product Information
          FormYellow solid
          Hill FormulaC₂₂H₂₂N₄O₂
          Chemical formulaC₂₂H₂₂N₄O₂
          ReversibleY
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TAZ Activator, IBS008738 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Yang, Z., et al. 2014. Mol. Cell. Biol. 34, 1607.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-December-2016 JSW
          Synonyms(4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone, Transcriptional Co-activator with PDZ-binding Motif (TAZ) Activator, WWTR1 Activator
          DescriptionA benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₂₂N₄O₂
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYang, Z., et al. 2014. Mol. Cell. Biol. 34, 1607.