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SKBM02560 Strat-M® Membrane, Transdermal Diffusion Test Model, 25mm

SKBM02560
60  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSKBM02560
      Trade Name
      • Strat-M
      DescriptionStrat-M® Membrane, Transdermal Diffusion Test Model, 25mm
      Background InformationStrat-M® Membrane for Transdermal Diffusion Testing
      Experience the unmatched predictability of Strat-M membrane – a synthetic, non-animal based model for transdermal diffusion testing that is predictive of diffusion in human skin without lot-to-lot variability, safety and storage limitations.

      Strat-M membrane is designed for screening of:
      •Active pharmaceutical ingredients (API)
      •Cosmetic actives
      •Formulations
      •Personal care products
      •Pesticides and chemicals

      Human Skin Correlation
      Strat-M membrane is predictive of diffusion in human skin for a wide range of compounds and formulations. Use the Compound Correlation Tool to learn how well Strat-M membrane will work for you.

      Reproducible Diffusion Data:
      No need to repeat testing each time a new lot of skin arrives in the lab. Strat-M membrane is a highly consistent, engineered material that allows you to compare today’s diffusion data with data you will generate next week, or next month. Furthermore, lot-to-lot consistency brings a new level of clarity to your test data, simplifying your analysis.

      Sensitive to Enhancers
      Strat-M membrane exhibits differential permeability in the presence of enhancers and is compatible with common formulation formats, so it is appropriate for use during formulation optimization.

      Ultimate Experimental Convenience
      Strat-M membrane was designed with convenience in mind. The Strat-M membrane is shelf-stable and stocked in the warehouse so procurement and storage is a breeze. Each membrane is individually packaged as precut discs and do not need to be hydrated prior to use. Simply remove the Strat-M membrane disc from its pouch and load into a Franz cell.
      References
      Product Information
      Filter CodeSKBM
      Filter ColorWhite
      Quality LevelMQ400
      Applications
      ApplicationStrat-M membrane is a synthetic, non-animal based model for transdermal diffusion testing that is predictive of diffusion in human skin without lot-to-lot variability, safety & storage limitations.
      Biological Information
      Physicochemical Information
      Dimensions
      Filter SurfacePlain
      Diameter2.5 cm
      Thickness300 µm
      Filter Diameter (⌀)25 mm
      Materials Information
      Chemistry
      • Polyethersulfone (PES)
      • Polyolefin (PO)
      • Synthetic Lipid post-treatment
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Packaging Information
      Material Size60
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overviewPub Med ID
      Membrane properties for permeability testing: Skin versus synthetic membranes
      Haq A, Dorrani M, Goodyear B, Joshi V, Michniak-Kohn B.
      Int J Pharm.  539  Issues 1–2, Pages 58-64  2018

      Show Abstract
      29366943 29366943
      A REVIEW OF THE CURRENT STATE OF THE ART OF PHYSIOLOGICALLY-BASED TESTS FOR MEASURING HUMAN DERMAL IN VITRO BIOAVAILABILITY OF POLYCYCLIC AROMATIC HYDROCARBONS (PAH) IN SOIL
      Beriro DJ, Cave MR, Wragg J, Thomas R, Wills G, Evans F.
      J Hazard Mater.   305  240-59  2016

      Show Abstract
      26686483 26686483
      PREDICTION OF SKIN PERMEATION BY CHEMICAL COMPOUNDS USING THE ARTIFICIAL MEMBRANE, STRAT-M™
      Uchida T, Kadhum WR, Kanai S, Todo H, Oshizaka T, Sugibayashi K
      Eur J Pharm Sci.  67  113-8  2015

      Show Abstract
      25447745 25447745
      IN VITRO SKIN MODELS AS A TOOL IN OPTIMIZATION OF DRUG FORMULATION.
      Flaten GE, Palac Z, Engesland A, Filipović-Grčić J, Vanić Ž, Škalko-Basnet N
      Eur J Pharm Sci.   75  10-24  2015

      Show Abstract
      25746955 25746955
      CURCUMIN-EUDRAGIT® E PO SOLID DISPERSION: A SIMPLE AND POTENT METHOD TO SOLVE THE PROBLEMS OF CURCUMIN.
      Li J, Lee IW, Shin GH, Chen X, Park HJ.
      Pharm Biopharm.  94  322-32  2015

      Show Abstract
      26073546 26073546
      PREPARATION OF A CAPSAICIN-LOADED NANOEMULSION FOR IMPROVING SKIN PENETRATION
      Kim JH, Ko JA, Kim JT, Cha DS, Cho JH, Park HJ, Shin GH.
      J Agric Food Chem.  62(3)  725-32  2014

      Show Abstract
      24417234 24417234
      IMPACT OF DIFFERENT VEHICLES FOR LASER-ASSISTED DRUG PERMEATION VIA SKIN: FULL-SURFACE VERSUS FRACTIONAL ABLATION.
      Lee WR, Shen SC, Aljuffali IA, Li YC, Fang JY.
      Pharm Res.  31(2)  382-93  2014

      Show Abstract
      24022680 24022680
      DERMAL TOXICITY ELICITED BY PHTHALATES: EVALUATION OF SKIN ABSORPTION, IMMUNOHISTOLOGY, AND FUNCTIONAL PROTEOMICS
      Tai-Long Pan, Pei-Wen Wang, Ibrahim A. Aljuffalic, Yi-Yun Hung, Chwan-Fwu Lin, Jia-You Fang
      Food Chem Toxicol.  65  105-14  2014

      Show Abstract
      24384410 24384410
      COMPARISON OF IN VITRO RELEASE RATES OF ACYCLOVIR FROM CREAM FORMULATIONS USING VERTICAL DIFFUSION CELLS.
      Nallagundla S, Patnala S, Kanfer I.
      AAPS PharmSciTech  15(4)  994-9  2014

      Show Abstract
      24824173 24824173