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533065 Seriniquinone - Calbiochem

Seriniquinone, Autophagy inducer

Seriniquinone - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dinaphtho[2,3-b:2ʹ,3ʹ-d]thiophene-5,7,12,13-tetraone, Autophagy Inducer, Seriniquinone

Primary Target: dermicidin
533065
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₈O₄S

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      Description
      OverviewA cell permeable dinaphthothiophenetetraone compound isolated from marine bacterium of the genus Serinicoccus that targets dermicidin and displays anti-cancer property against a wide range of cancer cell lines (mean GI = 758 nM, LC50 = 13.2 µM in NCI-60 panel). Exhibits highest potency against melanoma cell lines. Following its uptake it localizes rapidly into endoplasmic reticulum and induces autophagocytosis as evidenced by increased conversion of LC3A-I and LC3B-I to LC3A-II and LC3B-II, respectively. Also shown to induce apoptosis in HCT-116 cells with increase in caspase-3, 7, and 9 activation and cleavage of poly(ADP-ribose) polymerase.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533065
      Brand Family Calbiochem®
      SynonymsDinaphtho[2,3-b:2ʹ,3ʹ-d]thiophene-5,7,12,13-tetraone, Autophagy Inducer, Seriniquinone
      DescriptionSeriniquinone
      References
      ReferencesTrzoss, L., et al. 2014. PNAS. 111, 14687.
      Product Information
      FormYellow solid
      Hill FormulaC₂₀H₈O₄S
      Chemical formulaC₂₀H₈O₄S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetdermicidin
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Seriniquinone - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Trzoss, L., et al. 2014. PNAS. 111, 14687.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2016 JSW
      SynonymsDinaphtho[2,3-b:2ʹ,3ʹ-d]thiophene-5,7,12,13-tetraone, Autophagy Inducer, Seriniquinone
      DescriptionA cell permeable dinaphthothiophenetetraone compound isolated from marine bacterium of the genus Serinicoccus that targets dermicidin and displays anti-cancer property against a wide range of cancer cell lines (mean GI = 758 nM, LC50 = 13.2 µM in NCI-60 panel). Exhibits highest potency against melanoma cell lines. Following its uptake it localizes rapidly into endoplasmic reticulum and induces autophagocytosis as evidenced by increased conversion of LC3A-I and LC3B-I to LC3A-II and LC3B-II, respectively. Also shown to induce apoptosis in HCT-116 cells with increase in caspase-3, 7, and 9 activation and cleavage of poly(ADP-ribose) polymerase.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₈O₄S
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTrzoss, L., et al. 2014. PNAS. 111, 14687.