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Description
Overview
This product has been discontinued.
A cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.
Catalogue Number
559307
Brand Family
Calbiochem®
Synonyms
7-Deaza-7-carbamoyladenosine, NSC-65346
References
References
Greene, N.M., et al. 1995. J. Biol. Chem. 270, 6710. Osada, H., et al. 1989. J. Antibiot. 42, 402. Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682. Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.
Very toxic by inhalation, in contact with skin and if swallowed.
S Phrase
S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sangivamycin - CAS 18417-89-5 - Calbiochem Certificates of Analysis
Title
Lot Number
559307
References
Reference overview
Greene, N.M., et al. 1995. J. Biol. Chem. 270, 6710. Osada, H., et al. 1989. J. Antibiot. 42, 402. Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682. Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-January-2010 RFH
Synonyms
7-Deaza-7-carbamoyladenosine, NSC-65346
Description
A cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.
Form
White solid
CAS number
18417-89-5
RTECS
UY9355000
Chemical formula
C₁₂H₁₅N₅O₅
Structure formula
Purity
≥98% by HPLC
Solubility
0.1 M KOH (5 mg/ml)
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Highly Toxic
References
Greene, N.M., et al. 1995. J. Biol. Chem. 270, 6710. Osada, H., et al. 1989. J. Antibiot. 42, 402. Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682. Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.