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572630 SU5402 - CAS 215543-92-3 - Calbiochem

572630
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₆N₂O₃ 215543-92-3

Pricing & Availability

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572630-1MG
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      Plastic ampoule 1 mg
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      572630-2MG
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          Glass bottle 2 mg
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          572630-500UG
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              Plastic ampoule 500 μg
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              Description
              OverviewA cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.
              Catalogue Number572630
              Brand Family Calbiochem®
              Synonyms3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
              References
              ReferencesMohammadi, M., et al. 1997. Science 276, 955.
              Product Information
              CAS number215543-92-3
              ATP CompetitiveY
              DeclarationNot available for sale in the United States.
              FormLyophilized solid
              Hill FormulaC₁₇H₁₆N₂O₃
              Chemical formulaC₁₇H₁₆N₂O₃
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Primary TargetFibroblast growth factor receptor 1 (FGFR1)
              Primary Target IC<sub>50</sub>10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SU5402 - CAS 215543-92-3 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              SU5402 - CAS 215543-92-3 - Calbiochem Certificates of Analysis

              TitleLot Number
              572630

              References

              Reference overview
              Mohammadi, M., et al. 1997. Science 276, 955.

              Citations

              Title
            • Marie-Claire Delfini, et al. (2005) Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proceedings of the National Academy of Science USA 102, 11343-11348.
            • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision19-April-2011 RFH
              Synonyms3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
              DescriptionA cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP) by interacting with the catalytic domain of FGFR1. Also inhibits aFGF-induced phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984, it acts only as a weak inhibitor of tyrosine phosphorylation of the PDGF receptor. Does not inhibit the phosphorylation of insulin receptor and exhibits no inhibitory effect on EGF receptor kinase.
              FormLyophilized solid
              CAS number215543-92-3
              Chemical formulaC₁₇H₁₆N₂O₃
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (25 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesMohammadi, M., et al. 1997. Science 276, 955.
              Citation
            • Marie-Claire Delfini, et al. (2005) Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proceedings of the National Academy of Science USA 102, 11343-11348.
            • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.