Product Information
Applications
Biological Information
Primary TargetSIRT1
Primary Target IC<sub>50</sub>98 nM against SIRT1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

SIRT1 Inhibitor III SDS

Title

Safety Data Sheet (SDS) 

SIRT1 Inhibitor III Certificates of Analysis

TitleLot Number
566322

References

Reference overview
Solomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-July-2007 JSW
Synonyms6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, EX-527, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I
DescriptionA cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number49843-98-3
Chemical formulaC₁₃H₁₃ClN₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesSolomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors