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506415 SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem

506415
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Key Specifications Table

Empirical FormulaCAS #
C₁₈H₂₈N₂O₃S·HCl 261901-57-9

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      Description
      OverviewA selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
      Catalogue Number506415
      Brand Family Calbiochem®
      Synonyms5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
      References
      ReferencesTokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
      Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
      Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
      Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.
      Product Information
      CAS number 261901-57-9
      FormOff-white solid
      Hill FormulaC₁₈H₂₈N₂O₃S·HCl
      Chemical formulaC₁₈H₂₈N₂O₃S·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT₇
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Tokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
      Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
      Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
      Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      Synonyms5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
      DescriptionA selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
      FormOff-white solid
      CAS number 261901-57-9
      Chemical formulaC₁₈H₂₈N₂O₃S·HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
      Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
      Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
      Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.