567734 S1P₁ Receptor Agonist III - Calbiochem

567734
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567734-10MG
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      Glass bottle 10 mg
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      Description
      OverviewAn orally bioavailable polar head group lacking carbamoylnicotinamide compound that acts as a potent and reversible agonist of hS1P1 receptor (EC50 = 35 nM with 96% efficacy) with substantial to excellent selectivity over hS1P5 (EC50 = 4.3 µM with 58% efficacy) and hS1P2-4 (EC50 > 25 µM). Minimally affects the activities of hERG (IC50 > 10 µM) and cytochrome p450 isozymes (IC50 > 30 µM for 3A4 and 2D6), and exhibits desirable microsomal stability and aqueous solubility, Shown to efficiently reduce the circulating lymphocyte levels in rats (1 mg/kg, p.o.).
      Catalogue Number567734
      Brand Family Calbiochem®
      Synonyms4-Methoxy-N-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)nicotinamide, Sphingosine-1-Phosphate₁ Receptor Agonist III
      References
      ReferencesPennington, L.D., et al. 2011. Bioorg. Med. Chem. Lett. 22, 527.
      Product Information
      FormWhite solid
      Hill FormulaC₂₁H₁₆F₃N₃O₃
      Chemical formulaC₂₁H₁₆F₃N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      S1P₁ Receptor Agonist III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Pennington, L.D., et al. 2011. Bioorg. Med. Chem. Lett. 22, 527.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2012 JSW
      Synonyms4-Methoxy-N-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)nicotinamide, Sphingosine-1-Phosphate₁ Receptor Agonist III
      DescriptionAn orally bioavailable polar head group lacking carbamoylnicotinamide compound that acts as a potent and reversible agonist of hS1P1 receptor (EC50 = 35 nM with 96% efficacy) with substantial to excellent selectivity over hS1P5 (EC50 = 4.3 µM with 58% efficacy) and hS1P2-4 (EC50 > 25 µM). Minimally affects the activities of hERG (IC50 > 10 µM) and cytochrome p450 isozymes (IC50 > 30 µM for 3A4 and 2D6), and exhibits desirable microsomal stability and aqueous solubility, Shown to efficiently reduce the circulating lymphocyte levels in rats (1 mg/kg, p.o.).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₁₆F₃N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPennington, L.D., et al. 2011. Bioorg. Med. Chem. Lett. 22, 527.