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504983 S18986 - CAS 175340-20-2 - Calbiochem

S18986 - CAS 175340-20-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide, (S)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide, AMPA Receptor Positive Allosteric Modulator, S18986

Primary Target: AMPA
504983
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
175340-20-2C₁₀H₁₂N₂O₂S

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      Description
      OverviewA positive allosteric modulator selective for the AMPA receptors. A nootropic and neuroprotective agents frequently used in researches studying cognition, memory, and aging related cognitive declines. Induces production of BNDF and AMPA-mediated release of noradrenaline and acetylcholine. Biologically viable admitted systematically.
      Catalogue Number504983
      Brand Family Calbiochem®
      Synonyms(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide, (S)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide, AMPA Receptor Positive Allosteric Modulator, S18986
      References
      ReferencesGupta, K., et al. 2009. Cell Death & Differentiation. 16, 624.
      Marighetto, A., et al. 2008. Beh. Pharmacol. 19, 235.
      Bloss, B., et al. 2008. Exp. Neurol. 210, 109.
      Lockhart, P., et al. 2007. Eur. J. Pharmacol. 561, 23.
      Munoz, C., et al. 2004. Neurobiol. Aging. 25, S224.
      Rosi, S., et al. 2004. Neurosci. Lett. 361, 120.
      Lebrun, C., et al. 2000. Eur. J. Pharmacol. 401, 205.
      Lockhart, B., et al. 2000. Eur. J. Pharmacol. 401, 145.
      Product Information
      CAS number175340-20-2
      FormWhite solid
      Hill FormulaC₁₀H₁₂N₂O₂S
      Chemical formulaC₁₀H₁₂N₂O₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAMPA
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      S18986 - CAS 175340-20-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Gupta, K., et al. 2009. Cell Death & Differentiation. 16, 624.
      Marighetto, A., et al. 2008. Beh. Pharmacol. 19, 235.
      Bloss, B., et al. 2008. Exp. Neurol. 210, 109.
      Lockhart, P., et al. 2007. Eur. J. Pharmacol. 561, 23.
      Munoz, C., et al. 2004. Neurobiol. Aging. 25, S224.
      Rosi, S., et al. 2004. Neurosci. Lett. 361, 120.
      Lebrun, C., et al. 2000. Eur. J. Pharmacol. 401, 205.
      Lockhart, B., et al. 2000. Eur. J. Pharmacol. 401, 145.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      Synonyms(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide, (S)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide, AMPA Receptor Positive Allosteric Modulator, S18986
      DescriptionA positive allosteric modulator selective for the AMPA receptors. A nootropic and neuroprotective agents frequently used in researches studying cognition, memory, and aging related cognitive declines. Induces production of BNDF and AMPA-mediated release of noradrenaline and acetylcholine. Biologically viable admitted systematically.
      FormWhite solid
      CAS number175340-20-2
      Chemical formulaC₁₀H₁₂N₂O₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGupta, K., et al. 2009. Cell Death & Differentiation. 16, 624.
      Marighetto, A., et al. 2008. Beh. Pharmacol. 19, 235.
      Bloss, B., et al. 2008. Exp. Neurol. 210, 109.
      Lockhart, P., et al. 2007. Eur. J. Pharmacol. 561, 23.
      Munoz, C., et al. 2004. Neurobiol. Aging. 25, S224.
      Rosi, S., et al. 2004. Neurosci. Lett. 361, 120.
      Lebrun, C., et al. 2000. Eur. J. Pharmacol. 401, 205.
      Lockhart, B., et al. 2000. Eur. J. Pharmacol. 401, 145.