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554325 Resveratrol - CAS 501-36-0 - Calbiochem

554325
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₁₄H₁₂O₃ 501-36-0

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554325-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewA phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      Catalogue Number554325
      Brand Family Calbiochem®
      Synonymstrans-3,4ʹ,5-Trihydroxystilbene
      References
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Lin, H.Y., et al. 2002. J. Urol. 168, 748.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
      Jang, M., et al. 1997. Science 275, 218.
      Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
      Product Information
      CAS number501-36-0
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₄H₁₂O₃
      Chemical formulaC₁₄H₁₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>ED50 = 15 µM against COX-1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Resveratrol - CAS 501-36-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Resveratrol - CAS 501-36-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      554325

      References

      Reference overview
      Howitz, K.T., et al. 2003. Nature 425, 191.
      Lin, H.Y., et al. 2002. J. Urol. 168, 748.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
      Jang, M., et al. 1997. Science 275, 218.
      Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonymstrans-3,4ʹ,5-Trihydroxystilbene
      DescriptionA phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      FormOff-white solid
      CAS number501-36-0
      Chemical formulaC₁₄H₁₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 8158
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Lin, H.Y., et al. 2002. J. Urol. 168, 748.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
      Jang, M., et al. 1997. Science 275, 218.
      Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.