480150 Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem

480150
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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₂₁ClN₄O 729605-21-4

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480150-5MG
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      5 mg
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      Description
      OverviewA cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC50 = 0.2 µM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 µM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC50 ≤11.3 nM).
      Catalogue Number480150
      Brand Family Calbiochem®
      SynonymsActin Assembly Inhibitor XVI, Ras Activation Inhibitor, Tubulin Polymerization Inhibitor IX, 1-(3-Chlorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl)piperazine
      References
      ReferencesWasylyk, C., et al. 2008. Cancer Res. 68, 1275.
      Product Information
      CAS number729605-21-4
      FormWhite solid
      Hill FormulaC₂₁H₂₁ClN₄O
      Chemical formulaC₂₁H₂₁ClN₄O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      480150

      References

      Reference overview
      Wasylyk, C., et al. 2008. Cancer Res. 68, 1275.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-February-2010 RFH
      SynonymsActin Assembly Inhibitor XVI, Ras Activation Inhibitor, Tubulin Polymerization Inhibitor IX, 1-(3-Chlorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl)piperazine
      DescriptionA cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC50 = 0.2 µM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 µM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC50 ≤11.3 nM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number729605-21-4
      Chemical formulaC₂₁H₂₁ClN₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM) or Ethanol (50 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWasylyk, C., et al. 2008. Cancer Res. 68, 1275.