508147 RS 127445 Hydrochloride - CAS 199864-86-3 - Calbiochem

508147
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Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₆FN₃·HCl 199864-86-3

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      Glass bottle 10 mg
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      Description
      OverviewA selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
      Catalogue Number508147
      Brand Family Calbiochem®
      References
      ReferencesSharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
      Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
      Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
      Product Information
      CAS number199864-86-3
      FormOff-white solid
      Hill FormulaC₁₇H₁₆FN₃·HCl
      Chemical formulaC₁₇H₁₆FN₃·HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Target5-HT2B
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Sharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
      Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
      Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-October-2013 JSW
      DescriptionA selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
      FormOff-white solid
      CAS number199864-86-3
      Chemical formulaC₁₇H₁₆FN₃·HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM) or Ethanol (100 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
      Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
      Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.