553514 RAD51 Inhibitor II, RI-1 - Calbiochem

553514
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₄H₁₁Cl₃N₂O₃

Pricing & Availability

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553514-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
      Catalogue Number553514
      Brand Family Calbiochem®
      Synonyms3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
      References
      ReferencesBudke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
      Product Information
      FormBright yellow solid
      Hill FormulaC₁₄H₁₁Cl₃N₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationRAD51 Inhibitor II, RI-1, CAS 415713-60-9, covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is needed for filament formation & recombinase activity.
      Biological Information
      Primary TargetRAD51
      Primary Target IC<sub>50</sub>5-30 µ
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      RAD51 Inhibitor II, RI-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      RAD51 Inhibitor II, RI-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      553514

      References

      Reference overview
      Budke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-September-2012 JSW
      Synonyms3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
      DescriptionA cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
      FormBright yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBudke, B., et al. 2012. Nucleic Acids Res. 40, 7347.