Product Information
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Pro-survival Compound, DDD00033325 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Pro-survival Compound, DDD00033325 - Calbiochem Certificates of Analysis

TitleLot Number
529659

References

Reference overview
Andrews, P.D., et al. 2010. Biochem. J. 432, 21.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2012 JSW
SynonymsDDD00033325
DescriptionA cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (>83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
FormYellow syrup
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₉N₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesAndrews, P.D., et al. 2010. Biochem. J. 432, 21.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology