Key Specifications Table
|Empirical Formula||CAS #|
Pricing & Availability
An invalid quantity was specified. The product quantity has been adjusted.
|5.04819.0001||Glass bottle||10 mg||
|Overview||A cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 (Cat. No. 681671) in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5 nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50 nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 (Cat. No. 681669) in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5 µM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice.|
|Synonyms||IWPL6, Wnt Pathway Inhibitor XIX|
|References||Wang, X., et al. 2013. J. Med. Chem. 56, 2700.|
|Structure formula Image|
|Purity||≥99% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem SDS
|Wang, X., et al. 2013. J. Med. Chem. 56, 2700.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.