533936 Sigma-AldrichPolo-like Kinase Inhibitor IV, BI 2536 - CAS 755038-02-9 - Calbiochem
Polo-Like Kinase IV, BI 2536, CAS 755038-02-9, is a cell-permeable, inhibitor of PLK1 (IC₅₀ = 830 pM). At higher concentrations blocks the activity of PLK2 & 3 (IC₅₀ = 3.5 & 9.0 nM, respectively).
More>> Polo-Like Kinase IV, BI 2536, CAS 755038-02-9, is a cell-permeable, inhibitor of PLK1 (IC₅₀ = 830 pM). At higher concentrations blocks the activity of PLK2 & 3 (IC₅₀ = 3.5 & 9.0 nM, respectively). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: BI-2536, 4-((R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide, PlK1 Inhibitor IV, BRD4 Inhibitor VII
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Overview
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Key Specifications Table
Empirical Formula |
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C₂₈H₃₉N₇O₃ |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.33936.0001 |
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Glass bottle | 10 mg |
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Product Information | |
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CAS number | 755038-02-9 |
Form | Light yellow solid |
Hill Formula | C₂₈H₃₉N₇O₃ |
Chemical formula | C₂₈H₃₉N₇O₃ |
Reversible | Y |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | PLK1 |
Primary Target IC<sub>50</sub> | 830 pM for PLK1 |
Secondary target | BRD4 |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Documentation
Polo-like Kinase Inhibitor IV, BI 2536 - CAS 755038-02-9 - Calbiochem SDS
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References
Reference overview |
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Ciceri, P., et al. 2014. Nat. Chem. Biol. 10, 305. Nappi, T.C., et al. 2009. Cancer Res. 69, 1916. Steegmaier M, et al. 2007. Curr. Biol. 17, 316. Lenart, P., et al. 2007. Curr. Biol. 17, 304. |