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528178 Plasminogen, EACA- and Lysine-Free, Human Plasma

528178
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528178-50U
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      Description
      OverviewNative plasminogen (EACA- and lysine-free) from human plasma. Plasminogen is a single chain glycoprotein found in normal plasma at ~12 mg per deciliter, and is the inactive precursor of the serine protease plasmin.
      Catalogue Number528178
      Brand Family Calbiochem®
      SynonymsProfibrinolysin, Plasma Trypsinogen
      References
      ReferencesSun, Z., et al. 2002. Biochim. Biophys. Acta 1596, 182.
      Robbins, K.C., et al. 1967. J. Biol. Chem. 242, 2333.
      Product Information
      CAS number9001-91-6
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1 µmol of N-tosyl-Gly-Pro-Lys-<i>p</i>NA per min at 25°C, pH 7.8.
      FormLyophilized
      FormulationLyophilized from 20 mM sodium phosphate buffer, 10 mg D-mannitol, 10 mg NaCl.
      Quality LevelMQ100
      Applications
      Biological Information
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity7 units/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for at least 1 week at 4°C or for 1-2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Plasminogen, EACA- and Lysine-Free, Human Plasma SDS

      Title

      Safety Data Sheet (SDS) 

      Plasminogen, EACA- and Lysine-Free, Human Plasma Certificates of Analysis

      TitleLot Number
      528178

      References

      Reference overview
      Sun, Z., et al. 2002. Biochim. Biophys. Acta 1596, 182.
      Robbins, K.C., et al. 1967. J. Biol. Chem. 242, 2333.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-November-2008 JSW
      SynonymsProfibrinolysin, Plasma Trypsinogen
      DescriptionNative plasminogen (EACA- and lysine-free) from human plasma. Single chain glycoprotein containing 790 amino acid residues. Found in normal plasma at about 12 mg/100 ml. Inactive precursor of the serine protease plasmin. It is converted to the active protease by cleavage at Arg560.
      FormLyophilized
      FormulationLyophilized from 20 mM sodium phosphate buffer, 10 mg D-mannitol, 10 mg NaCl.
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number9001-91-6
      Specific activity7 units/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1 µmol of N-tosyl-Gly-Pro-Lys-pNA per min at 25°C, pH 7.8.
      SolubilityH₂O
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for at least 1 week at 4°C or for 1-2 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 7521
      ReferencesSun, Z., et al. 2002. Biochim. Biophys. Acta 1596, 182.
      Robbins, K.C., et al. 1967. J. Biol. Chem. 242, 2333.