Pellicon® 2 Ultrafiltration CassettesDesigned with process scale-up and applications development in mind.
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Pellicon® 3 CassettesAdvanced, high performance cassettes ideally suited to today's demanding filtration processes that require more rigorous operating pressures, temperatures and caustic cleaning regimes
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|Biopharmaceutical Manufacturing > Downstream Processing > Ultrafiltration > Pellicon Ultrafiltration|
Pellicon® single-pass tangential flow filtration (single-pass TFF) is a versatile ultrafiltration technology for more productive, high capacity and cost effective downstream processes that allows facilities to meet the demands of high titer and connected or continuous processes.
To run single-pass TFF, Pellicon® cassettes are installed in existing Pellicon® holders and the serial flow path is generated by use of specially designed diverter plates. The Pellicon® single-pass TFF mini kit is ideally suited for small-scale applications with mini cassettes. Larger diverter plates are available for process scale-up.
Single-pass TFF is ideal for:
- Achieving high concentrations and high yields
- In-process volume concentration for improved facility fit
- Intensified performance of chromatography and filtrations steps
- Connected and continuous processes
Integration of single-pass TFF into a biomanufacturing process is easy with Pellicon® single-pass TFF accessories and existing, proven Pellicon® cassettes. Our high performance Pellicon® cassettes deliver high protein yield and consistent product purity and quality, from run to run at every scale and for a variety of drug products.
- Easy installation and assembly operation
- Use with existing Pellicon® holders and cassettes
- Supports scale-down and scale-up applications
- Enables intensified, connected and continuous processes
- Monoclonal antibodies
- Recombinant and non-recombinant proteins
|Materials of Construction|
|Mini Cassette Diverter Plate (part of kit)||Polysulfone|
|Mini Cassette Gasket (part of kit)||Silicone|
|Cassette Diverter Plate||316L stainless steel|
|Cassette Retentate Collection Plate||316L stainless steel|
|Maximum Operating Conditions|
|Maximum Operating Pressure||40 psi (2.7 bar) at 50oC, 80 psi (5.5 bar) at 40oC|
|Maximum Caustic Exposure||1.0N NaOH up to 50 hours|
|Operating pH Range||2-13|
|Component Material Toxicity||Mini diverter plate component materials meet the criteria of the USP USP <88> Reactivity Test for Class VI Plastics.|
|FDA 21 CFR||Mini diverter plate component materials meet the criteria for compliance with 21 CFR 177-1655 for plastic components.|