520222 PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem

520222
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₃₃N₆O₃Cl₃ 142036-63-3

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
520222-25MG
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      Plastic ampoule 25 mg
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      520222-5MG
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      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
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          Plastic ampoule 5 mg
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          Description
          OverviewExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H2O (Cat. No. 508773).
          Catalogue Number520222
          Brand Family Calbiochem®
          References
          ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
          Product Information
          CAS number142036-63-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₁H₃₃N₆O₃Cl₃
          Chemical formulaC₂₁H₃₃N₆O₃Cl₃
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationPPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.
          Biological Information
          Primary TargetThrombin
          Primary Target IC<sub>50</sub>Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin
          Purity≥80% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          520222

          References

          Reference overview
          Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

          Citations

          Title
        • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2013 JSW
          DescriptionExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number142036-63-3
          Chemical formulaC₂₁H₃₃N₆O₃Cl₃
          Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
          Purity≥80% by HPLC
          SolubilityH₂O (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
          Toxicity Standard Handling
          Merck USA index14, 7699
          ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
          Citation
        • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.