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531551 PKR/PERK Activator, DHBDC - Calbiochem

531551
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₂O₆

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable chromenone derivative that acts as a dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IkBa and thereby activates NF-κB pathway. However, the activation of NF-κB is independent of PKR activity. Induces elF2a phosphorylation and activates its downstream effectors CHOP/GADD153. Does not affect the phosphorylation of Akt, MAP kinase, or 4E-BP1. Inhibits the expression of cyclin D1 and E and blocks the growth of CRL-2813 and MCF-7 cells (IC50 = ~ 10 µM). Also shown to reduce JFH1 hepatitis C virus infectivity (~40% inhibition at 5 µM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531551
      Brand Family Calbiochem®
      SynonymsProtein Kinase R (PKR) Activator, Protein Kinase R Like Kinase (PERK) Activator
      References
      ReferencesBai, H., et al. 2013. ChemBioChem 14, 1255.
      Product Information
      FormPink powder
      Hill FormulaC₁₇H₁₂O₆
      Chemical formulaC₁₇H₁₂O₆
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKR and PERK
      Primary Target IC<sub>50</sub>~ 10 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PKR/PERK Activator, DHBDC - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Bai, H., et al. 2013. ChemBioChem 14, 1255.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2014 JSW
      SynonymsProtein Kinase R (PKR) Activator, Protein Kinase R Like Kinase (PERK) Activator
      DescriptionA cell permeable chromenone derivative that acts as a dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IkBa and thereby activates NF-κB pathway. However, the activation of NF-κB is independent of PKR activity. Induces elF2a phosphorylation and activates its downstream effectors CHOP/GADD153. Does not affect the phosphorylation of Akt, MAP kinase, or 4E-BP1. Inhibits the expression of cyclin D1 and E and blocks the growth of CRL-2813 and MCF-7 cells (IC50 = ~ 10 µM). Also shown to reduce JFH1 hepatitis C virus infectivity (~40% inhibition at 5 µM).
      FormPink powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₂O₆
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBai, H., et al. 2013. ChemBioChem 14, 1255.