Product Information
Applications
ApplicationPKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
Biological Information
Primary TargetPKR
Primary Target IC<sub>50</sub>210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

PKR Inhibitor - CAS 608512-97-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PKR Inhibitor - CAS 608512-97-6 - Calbiochem Certificates of Analysis

TitleLot Number
527450

References

Reference overview
Zhu, P.J., et al. 2011. Cell 147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2018 JSW
SynonymsPKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
DescriptionAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Inactive control is also available (Cat. No. 527455).
FormOrange to orange brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number608512-97-6
Chemical formulaC₁₃H₈N₄OS
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > RNA-Dependent Protein Kinase Inhibitors