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524611 PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem

524611
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₅H₂₁N₇O₃ 371942-69-7

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524611-5MG
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      Description
      OverviewA cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110α (IC50 = 3.3 µM) and little activity against type IIγ PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.
      Catalogue Number524611
      Brand Family Calbiochem®
      Synonyms6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3ʹ2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide, PtdIns3P 5-KInase Inhibitor, YM201636
      References
      ReferencesJefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.
      Product Information
      CAS number371942-69-7
      FormWhite solid
      Hill FormulaC₂₅H₂₁N₇O₃
      Chemical formulaC₂₅H₂₁N₇O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      524611

      References

      Reference overview
      Jefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-January-2009 RFH
      Synonyms6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3ʹ2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide, PtdIns3P 5-KInase Inhibitor, YM201636
      DescriptionA cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110α (IC50 = 3.3 µM) and little activity against type IIγ PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number371942-69-7
      Chemical formulaC₂₅H₂₁N₇O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (1 mg/ml). Enhanced solubility in DMSO can be achieved by the addition of a small drop of TFA.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.