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500499 PI 3-K Inhibitor XVIII - Calbiochem

500499
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₁₈H₂₀₂N₃₂O₃₅

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      Glass bottle 10 mg
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      Description
      OverviewAn N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide (aa 514-537 in p110β C2-helical linker region) that prevents Gβγ-, but not RTK-, mediated p100β activation both in cell-free assays (1 µM) and in cultures (30 µM in p110β/p85/Akt/Gβγ-transfected HEK 293E cells) without affecting basal p100β activity, p110β-Rab5 interaction, nor Gβγ-dependent activation of adenylyl cyclase or p101-p110γ dimer. The ATP-competitive p110β inhibitior TGX-221 (Cat. No. 528113) can be used in conjunction for studying Gβγ dependency of p110β-mediated cellular functions.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number500499
      Brand Family Calbiochem®
      Synonymsp110β-Gβγ Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFLPV-NH₂
      References
      ReferencesDbouk, H.A., et al. 2012. Sci. Signal. 5, ra89.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₁₈H₂₀₂N₃₂O₃₅
      Chemical formulaC₁₁₈H₂₀₂N₃₂O₃₅
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGβγ subunit of G-proteins
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceN-Myr-Lys-Ala-Ala-Glu-Ile-Ala-Ser-Ser-Asp-Ser-Ala-Asn-Val-Ser-Ser-Arg-Gly-Gly-Lys-Lys-Phe-Leu-Pro-Val-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PI 3-K Inhibitor XVIII - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Dbouk, H.A., et al. 2012. Sci. Signal. 5, ra89.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-May-2013 JSW
      Synonymsp110β-Gβγ Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFLPV-NH₂
      DescriptionA PI 3-K p110β-derived Gβγ-binding peptide (aa 514-537 in p110β C2-helical linker region) is made cell-permeable via N-myristoylation and prevents Gβγ-, but not RTK-, mediated p110β activation both in cell-free immune complex activation assays (complete inhibition by 1 µM peptide) and in cultures (complete inhibition of pAKT T308 by 30 min 30 µM peptide treatment of p110β/p85/Akt/Gβγ-transfected HEK 293E cells) without affecting basal p110β activity, p110β-Rab5 interaction, nor Gαβ-dependent activation of adenylyl cyclase or p101-p110γ dimer. The ATP-competitive p110β inhibitior TGX-221 (Cat. No. 528113) can be used in conjunction for studying Gβγ-dependency of p110β-mediated cellular functions.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₁₈H₂₀₂N₃₂O₃₅
      Peptide SequenceN-Myr-Lys-Ala-Ala-Glu-Ile-Ala-Ser-Ser-Asp-Ser-Ala-Asn-Val-Ser-Ser-Arg-Gly-Gly-Lys-Lys-Phe-Leu-Pro-Val-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (25 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDbouk, H.A., et al. 2012. Sci. Signal. 5, ra89.