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509664 PDX1 Inducer, BRD7552 - Calbiochem

A cell permeable, reversible inducer of PDX1 expression. Its action is dependent on the presence of FOXA2 in cells.

PDX1 Inducer, BRD7552 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pancreatic and Duodenal Homeobox 1 Inducer

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509664
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₃H₃₃N₃O₁₅

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      		 Glass bottle 5 mg
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      Description
      OverviewA cell permeable, glucose-derived diversity oriented synthesized compound that acts as reversible inducer of PDX1 expression in human PANC-1 cells, primary human islets, and human duct derived cells in a dose-and time-dependent manner with maximal effect observed on day 9 at 5 µM. Its action is dependent on the presence of FOXA2 in cells as FOXA2 knockdown cells treated with this compound do not exhibit any effect on PDX1 expression. Shown to increase H3 acetylation and H3K4me3 and reduce H3K9me3, which is consistent with its transcriptional activation of PDX1. Prolonged treatment of PANC-1 cells (9 days) increases the expression of insulin mRNA and proteins levels. Does not affect cell number and does not influence apoptotic cell death in PANC-1 cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509664
      Brand Family Calbiochem®
      SynonymsPancreatic and Duodenal Homeobox 1 Inducer
      References
      ReferencesYuan, Y., et al. 2013. Chem. Bio. 20, 1513.
      Product Information
      FormWhite powder
      Hill FormulaC₃₃H₃₃N₃O₁₅
      Chemical formulaC₃₃H₃₃N₃O₁₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PDX1 Inducer, BRD7552 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Yuan, Y., et al. 2013. Chem. Bio. 20, 1513.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2014 JSW
      SynonymsPancreatic and Duodenal Homeobox 1 Inducer
      DescriptionA cell permeable, glucose-derived diversity oriented synthesized compound that acts as reversible inducer of PDX1 expression in human PANC-1 cells, primary human islets, and human duct derived cells in a dose-and time-dependent manner with maximal effect observed on day 9 at 5 µM. Its action is dependent on the presence of FOXA2 in cells as FOXA2 knockdown cells treated with this compound do not exhibit any effect on PDX1 expression. Shown to increase H3 acetylation and H3K4me3 and reduce H3K9me3, which is consistent with its transcriptional activation of PDX1. Prolonged treatment of PANC-1 cells (9 days) increases the expression of insulin mRNA and proteins levels. Does not affect cell number and does not influence apoptotic cell death in PANC-1 cells.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₃H₃₃N₃O₁₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO.
      Toxicity Standard Handling
      ReferencesYuan, Y., et al. 2013. Chem. Bio. 20, 1513.