234490 PD 153035 - CAS 153436-54-5 - Calbiochem

234490
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₁₆H₁₄BrN₃O₂ 153436-54-5

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234490-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
      Catalogue Number234490
      Brand Family Calbiochem®
      SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
      References
      ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Product Information
      CAS number153436-54-5
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
      FormWhite solid
      Hill FormulaC₁₆H₁₄BrN₃O₂
      Chemical formulaC₁₆H₁₄BrN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>25 pM
      Primary Target K<sub>i</sub>6 pM against epidermal growth factor receptor (EGFR)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PD 153035 - CAS 153436-54-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PD 153035 - CAS 153436-54-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      234490

      References

      Reference overview
      Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Fry, D.W., et al. 1994. Science 265, 1093.

      Citations

      Title
    • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
      DescriptionAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
      FormWhite solid
      CAS number153436-54-5
      Chemical formulaC₁₆H₁₄BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Citation
    • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.