Millipore Sigma Vibrant Logo

505328 PARP Inhibitor Set II - Calbiochem

PARP Inhibitor Set II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (R)- & (S)-& 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide, ME0328, ME0327, ARTD3 inhibitor, PARP3 Inhibitor, Poly-ADP-ribose Polymerase Inhibitor XVI

Primary Target: PARP3
505328
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₉H₁₉N₃O₂

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.05328.0001
Retrieving availability...
—
Fulfilment and delivery delayed Fulfilment and delivery delayed
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 1 set
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable, non-toxic, 4-oxo-3H-quinazolin derivative that acts as a highly potent and specific inhibitor of ADP-ribosyltransferase diphtheria toxin-like 3 (ARTD3/PARP3, IC50 = 890 pM) that targets its nicotinamide binding site, with >7-fold selectivity over ARTD1 (IC50 = 6.3 µM) and >12-fold selectivity over ARTD2 (IC50 = 10.8 µM), and without observable activities for the rest of 11 ARTDs profiled (IC50 >30 µM). Shown to elicit a concentration dependent retention of γH2AX containing foci in A549 cells following g-irradiation-induced DNA damage. A negative control enantiomer ME0327 that is inactive for ARTD3 is also included.
      Catalogue Number505328
      Brand Family Calbiochem®
      Synonyms(R)- & (S)-& 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide, ME0328, ME0327, ARTD3 inhibitor, PARP3 Inhibitor, Poly-ADP-ribose Polymerase Inhibitor XVI
      References
      ReferencesLindgren, A., et al, 2013, ACS Chem. Biol. 8, 1698.
      Product Information
      FormSolid
      Formulation1 set consists of 5 MG PARP Inhibitor XVI, PARP3-Selective, ME0328 (Cat. No. 505329) and 5 MG ME0327, Negative Control (Cat. No. 505330).
      Hill FormulaC₁₉H₁₉N₃O₂
      Chemical formulaC₁₉H₁₉N₃O₂
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPARP3
      Primary Target IC<sub>50</sub>890pM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Lindgren, A., et al, 2013, ACS Chem. Biol. 8, 1698.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-November-2013 JSW
      Synonyms(R)- & (S)-& 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide, ME0328, ME0327, ARTD3 inhibitor, PARP3 Inhibitor, Poly-ADP-ribose Polymerase Inhibitor XVI
      DescriptionA cell-permeable, 4-oxo-3H-quinazolin derivative whose (S) enantiomer, ME0328, acts as an active site-targeting, ADP-ribosyltransferase diphtheria toxin-like 3/ARTD3/PARP3-selective inhibitor (IC50 = 890 nM), while exhibiting much reduced or little activity against ARTD1/2/4/5/6/7/8/10/12/15 (IC50 >30 µM). Effectively delays cellular DNA repair following γ-irradiation (2 Gy) in human alveolar basal epithelial A549 and primary fetal lung fibrolast MRC5 cultures (1 h pretreatment at 0.1 to 30 µM prior to IR) with no detectable cytotoxicity up to 72 h at 10 µM. The inactive (R) enantiomer, ME0327, is also included.
      FormSolid
      Formulation1 set consists of 5 MG PARP Inhibitor XVI, PARP3-Selective, ME0328 (Cat. No. 505329) and 5 MG ME0327, Negative Control (Cat. No. 505330).
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₁₉N₃O₂
      Purity≥99% by HPLC
      SolubilityEach compound is soluble at 25 mg/ml in DMSO.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLindgren, A., et al, 2013, ACS Chem. Biol. 8, 1698.