532999 Orai1 Inhibitor, AnCoA4 - Calbiochem

532999
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₁₈O₆

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, non-toxic, tricyclic chromone-fused analog that directly binds to the C-terminus region of Orai 1 and reduces its binding to STIM1 and blocks Ca2+ influx through the store operated calcium (SOC) channel (EC50 = 880 nM). Its binding to Orai 1 is localized to the region that controls channel gating and interaction with STIM1. Does not affect voltage-gated Ca2+ channels even at higher concentrations (~ 10 µM). Shown to be more effective if administered before STIM1 begins interacting with Orai 1. Also shown to inhibit the expression genes involved in T cell activation and blocks Jurkat T cell proliferation (~ 10 µM). Reduces lymphohistiocytic inflammation without causing any neutrophil and tissue damage.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532999
      Brand Family Calbiochem®
      SynonymsCRAC Inhibitor II
      References
      ReferencesSadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.
      Product Information
      FormPale yellow solid
      Hill FormulaC₂₂H₁₈O₆
      Chemical formulaC₂₂H₁₈O₆
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetOrail1
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Orai1 Inhibitor, AnCoA4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Sadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2015 JSW
      SynonymsCRAC Inhibitor II
      DescriptionA cell-permeable, non-toxic, tricyclic chromone-fused analog that directly binds to the C-terminus region of Orai 1 and reduces its binding to STIM1 and blocks Ca2+ influx through the store operated calcium (SOC) channel (EC50 = 880 nM). Its binding to Orai 1 is localized to the region that controls channel gating and interaction with STIM1. Does not affect voltage-gated Ca2+ channels even at higher concentrations (~ 10 µM). Shown to be more effective if administered before STIM1 begins interacting with Orai 1. Also shown to inhibit the expression genes involved in T cell activation and blocks Jurkat T cell proliferation (~ 10 µM). Reduces lymphohistiocytic inflammation without causing any neutrophil and tissue damage.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₁₈O₆
      Purity≥96% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.