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Non-cell-based Assays for Drug Transport

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Overview

Specifications

Ordering Information

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MultiScreen Permeability Plate with .45 µm Polycarbonate MembraneClear Sorting & Filtering Show Filter
Catalog NumberDescriptionPack Size
MPC4NTR10MultiScreen Permeability Filter Plate, 0.4 µm, non-sterile 10 Show Pricing & Availability

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MultiScreen-IP Plate with 0.45 µm PVDF Membrane (with underdrain)Clear Sorting & Filtering Show Filter
Catalog NumberDescriptionPack Size
MAIPN4550MultiScreen-IP Filter Plate, 0.45 µm, clear, non-sterile 50 Show Pricing & Availability

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MultiScreen-IP Plate with 0.45 µm PVDF Membrane (without underdrain)Clear Sorting & Filtering Show Filter
Catalog NumberDescriptionPack Size
MAIPNTR10MultiScreen IP Filter Plate, 0.45 µm, clear, non-sterile 10 Show Pricing & Availability

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MultiScreen Acceptor 96-well PTFEClear Sorting & Filtering Show Filter
Catalog NumberDescriptionPack Size
MSSACCEPT0R96 well Collection Plate 1 Show Pricing & Availability

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AccessoriesClear Sorting & Filtering Show Filter
Catalog NumberDescriptionPack Size
MSCPNUV4096-well Collection Plate 40 Show Pricing & Availability
MATRNPS5096 well Collection Plate 50 Show Pricing & Availability

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Documentation

Technical Info

Title
Automation of PAMPA-HDM using a MultiScreen Filter Plate on a Beckman Biomek FX Workstation
Automation of PAMPA-Lipid using a MultiScreen-IP PAMPA Filter Plate on a ScicloneTM ALH 3000 Advanced Liquid Handler Workstation
Combining Permeability and Solubility Analyses in a Single Workflow
HDM-PAMPA with the MultiScreen Permeability Filter Plate
Membrane Integrity test for Lipid-PAMPA Artificial Membranes
MultiScreen Filter Plates for PAMPA: Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA)
MultiScreen Permeability Plates: The evaluation of the reproducibility of passive, transcellular drug permeability assays

Data Sheet

Title
MultiScreen Transport and PTFE Receiver Plates

Posters

Title
Automation of ADME Applications

References

Reference overview
Relationship between structure and high-througput screening permability of diverse drugs with artifical membranes: Application to prediction of Caco-2 cell permeability.
Masaaki Fujikawa, Rieko Ano, Kazuya Nakao, Ryo Shimizu and Miki Akamatsu
Bioorganic & Medicinal Chemistry  2005

A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis.
Balimane, P.V., Pace, E., Chong, S., Zhu, M., Jemal, M., VanPelt, C.K.
Journal of Pharmaceutical and Biomedical Analysis 39 (2005): 8-16  2005

Use of ADME screening to conserve resources in drug discovery and development
Weiss, A. and Joseph Machamer
American Biotechnology Laboratory, January 2004: 16-17  2004

Screening for pharma gold: Researchers are using membrane technologies for high-throughput ADME analysis
Lynch, John,Modern Drug Discovery, January 2004: 27-28
Modern Drug Discovery, January 2004: 27-28  2004

Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability
Rieko Ano, Yukitaka Kimura, Motohiro Shima, Ryuichi Matsuno, Tamio Ueno and Miki Akamatsu
Bioorganic & Medicinal Chemistry 12 (2004) 257-264  2004

Prediction of human intestinal permeability using artificial membrane permeability
Kiyohiko Sugano, Yoshiaki Nabuchi, Minoru Machida and Yoshinori Aso
International Journal of Pharmaceutics 257 (2003) 245-251  2003

FAQ

QuestionAnswer
What material is the underdrain support to the Multiscreen plates made of?The underdrain support is made of polyethylene.
What is the well depth and maximum volume capacity of a MultiScreen plate?The well depth of a 96 well MultiScreen plate is 1.245 cm. The well depth for a 384 well MultiScreen plate is 1.2 cm. The maximum working volume of a 96 well plate is 300 ul. The maximum working volume for a 384 well plate is 100 ul.

User Guides

Title
MultiScreen Immobilon-P Filtration Plates
MultiScreen Permeability Plate Assembly
MultiScreen® 96-well Transport Receiver Plate User Guide
MultiScreen® Permeability Filter Plate Assembly User Guide