488004 Nodinitib-1 - Calbiochem

488004
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₄H₁₃N₃O₂S

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
488004-10MG
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      Overview

      This product has been discontinued.



      A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.

      Catalogue Number488004
      Brand Family Calbiochem®
      SynonymsCID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor
      References
      ReferencesKhan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
      Correa, R.G., et al. 2011. Chem. Biol. 18, 825.
      Product Information
      FormWhite powder
      Hill FormulaC₁₄H₁₃N₃O₂S
      Chemical formulaC₁₄H₁₃N₃O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Nodinitib-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Nodinitib-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      488004

      References

      Reference overview
      Khan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
      Correa, R.G., et al. 2011. Chem. Biol. 18, 825.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      SynonymsCID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor
      DescriptionA cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₁₃N₃O₂S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml; clear, colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKhan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
      Correa, R.G., et al. 2011. Chem. Biol. 18, 825.