500526 NOX Inhibitor VII, Thr101 - Calbiochem

500526
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₄H₁₀FNOS

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phox bis-SH3 binding (IC50 = 4 vs. 0.3 µM) and NOX2 activity (IC50 = 4 vs. 0.6 µM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 µM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number500526
      Brand Family Calbiochem®
      Synonyms6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one, NADPH Oxidase Inhibitor VII
      References
      ReferencesSmith, S.M.E., et al. 2012. Chem. Biol. 19, 752.
      Product Information
      FormLight brown powder
      Hill FormulaC₁₄H₁₀FNOS
      Chemical formulaC₁₄H₁₀FNOS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NOX Inhibitor VII, Thr101 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NOX Inhibitor VII, Thr101 - Calbiochem Certificates of Analysis

      TitleLot Number
      500526

      References

      Reference overview
      Smith, S.M.E., et al. 2012. Chem. Biol. 19, 752.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-October-2013 JSW
      Synonyms6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one, NADPH Oxidase Inhibitor VII
      DescriptionA cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phox bis-SH3 binding (IC50 = 4 vs. 0.3 µM) and NOX2 activity (IC50 = 4 vs. 0.6 µM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 µM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.
      FormLight brown powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₁₀FNOS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSmith, S.M.E., et al. 2012. Chem. Biol. 19, 752.