Millipore Sigma Vibrant Logo

480420 NF449 - CAS 627034-85-9 - Calbiochem

NF449, CAS 627034-85-9, is a potent Gsα-subunit-selective G-protein antagonist. Suppresses GTPγS binding to Gsα-s-subunit (IC50 = 140 nM). A highly potent P2X1 receptor antagonist (IC50 = 280 pM).

NF449 - CAS 627034-85-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)

Primary Target: Gsα-subunit-selective G-protein antagonist
480420
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
627034-85-9C₄₁H₂₄N₆O₂₉S₈ · 8Na

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
480420-10MG
Retrieving availability...
—
Fulfilment and delivery delayed Fulfilment and delivery delayed
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA potent Gsα-subunit-selective G-protein antagonist. Suppresses the rate of GTPγS binding to Gsα-s-subunit (IC50 = 140 nM) but not to Giα-1-subunit. Inhibits stimulation of adenylate cyclase activity in S49 cyc- cells (which lack endogenous Gsα-subunit) by exogenously added Gsα-subunit. Also blocks the coupling of β-adrenergic receptors to Gs (EC50 = 7.9 µM).
      Catalogue Number480420
      Brand Family Calbiochem®
      Synonyms4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)
      References
      ReferencesHulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
      Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
      Product Information
      CAS number627034-85-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
      Chemical formulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNF449, CAS 627034-85-9, is a potent Gsα-subunit-selective G-protein antagonist. Suppresses GTPγS binding to Gsα-s-subunit (IC50 = 140 nM). A highly potent P2X1 receptor antagonist (IC50 = 280 pM).
      Biological Information
      Primary TargetGsα-subunit-selective G-protein antagonist
      Primary Target IC<sub>50</sub>140 nM suppressing the rate of GTPγS binding to Gsα-s-subunit
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NF449 - CAS 627034-85-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NF449 - CAS 627034-85-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      480420

      References

      Reference overview
      Hulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
      Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2020 JSW
      Synonyms4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)
      DescriptionA potent Gsα-selective G-protein antagonist. Suppresses the rate of GTPγS binding to Gsα-s (IC50 = 140 nM) but not in Giα-1. Inhibits stimulation of adenylate cyclase activity in S49 cyc cells (which lack endogenous Gsα) by exogenously added Gsα-s. Also blocks the coupling of β-adrenergic receptors to Gs (EC50 = 7.9 µM). Acts as a reversible competitive antagonist of the human P2X receptor, exhibiting much higher potency at human P2X(1) than at P2X(7) receptors (IC50 = 50 nM vs 40 µM respectively).
      FormWhite solid
      CAS number627034-85-9
      Chemical formulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilitydH₂O (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
      Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.