505477 Sigma-AldrichNAE Inhibitor, MLN4924 - CAS 951950-33-7 - Calbiochem
NAE Inhibitor, MLN4924, CAS 951950-33-7, is an AMP mimetic that forms a NAE-catalyzed NEDD8 adduct, which acts as a tight-binding, ATP-competitive NAE inhibitor (IC50 = 4.7 nM).
More>> NAE Inhibitor, MLN4924, CAS 951950-33-7, is an AMP mimetic that forms a NAE-catalyzed NEDD8 adduct, which acts as a tight-binding, ATP-competitive NAE inhibitor (IC50 = 4.7 nM). Less<<Synonyms: ((1S,2S,4R)-4-(4-((1S)-2,3-Dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulphamate, NEDD8-Activating Enzyme Inhibitor
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Overview
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Key Specifications Table
CAS # | Empirical Formula |
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951950-33-7 | C₂₁H₂₅N₅O₄S |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.05477.0001 |
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Glass bottle | 5 mg |
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References | |
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References | Milhollen, M.A., et al. 2010. Blood 116, 1515. Brownell, J.E., et al. 2010. Mol. Cell 37, 102. Soucy, T.A., et al. 2009. Nature 458, 73. |
Product Information | |
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CAS number | 951950-33-7 |
Form | Light beige solid |
Hill Formula | C₂₁H₂₅N₅O₄S |
Chemical formula | C₂₁H₂₅N₅O₄S |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | NEDD8-Activating Enzyme |
Primary Target IC<sub>50</sub> | 4.7 nM) |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Safety Information according to GHS |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalog Number | GTIN |
5.05477.0001 | 04055977243857 |
Documentation
NAE Inhibitor, MLN4924 - CAS 951950-33-7 - Calbiochem SDS
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References
Reference overview |
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Milhollen, M.A., et al. 2010. Blood 116, 1515. Brownell, J.E., et al. 2010. Mol. Cell 37, 102. Soucy, T.A., et al. 2009. Nature 458, 73. |