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509886 Myristoylated Myr-KFEEERARAKWDT, mP13 - Calbiochem

A cell-permeable, myristoylated 13-mer peptide that inhibits talin association with β3. Inhibits both inside-out and outside-in signaling.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Integrin Signaling inhibitor II, mP13

Primary Target: Integrin alphaIIbbeta3
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509886
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₈₇H₁₃₈N₂₂O₂₄

Pricing & Availability

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      Description
      OverviewA cell-permeable, myristoylated 13-mer peptide derived from EXE-motif-containing integrin β3 subunit that inhibits talin association with β3. Shown to inhibit both inside-out and outside-in signaling. Blocks all phases of integrin signaling including fibrinogen binding, platelet adhesion, and clot retraction.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509886
      Brand Family Calbiochem®
      SynonymsIntegrin Signaling inhibitor II, mP13
      References
      ReferencesShen, B., et al. 2013. Nature 503, 131.
      Product Information
      FormWhite powder
      Hill FormulaC₈₇H₁₃₈N₂₂O₂₄
      Chemical formulaC₈₇H₁₃₈N₂₂O₂₄
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIntegrin alphaIIbbeta3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceKFEEERARAKWDT
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Myristoylated Myr-KFEEERARAKWDT, mP13 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Shen, B., et al. 2013. Nature 503, 131.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-May-2014 JSW
      SynonymsIntegrin Signaling inhibitor II, mP13
      DescriptionA cell-permeable, myristoylated 13-mer peptide derived from EXE-motif-containing integrin β3 subunit that inhibits talin association with β3. Shown to inhibit both inside-out and outside-in signaling. Blocks all phases of integrin signaling including fibrinogen binding, platelet adhesion, and clot retraction.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₈₇H₁₃₈N₂₂O₂₄
      Peptide SequenceKFEEERARAKWDT
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml). Not water soluble.
      Storage Protect from light
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShen, B., et al. 2013. Nature 503, 131.