Product Information
Applications
Biological Information
Primary Targettubulin
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

References

Reference overview
Ibbeson, B. M., et al. 2014. Nature Comm. 5, 3155.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-March-2015 JSW
Synonyms(1R,4S,5S)-methyl 4-(2-(benzo[b]thiophen-2-yl)phenyl)bicyclo[3.2.1]oct-2-ene-2-carboxylate, Mitosis Inhibitor II, (S)-Dosabulin and Negative Control Set
DescriptionA cell-permeable bridged bicycle heptene derived compound that can arrest mitosis (EC50 = 1.23 µM) by inducing tubulin depolymerization. Inhibits the growth of U2OS osteosarcoma cells (IC50 = 810 nM) and cause apoptotic cell death. Does neither affect the binding of vinblastine to tubulin nor does it displace colchicine, but is suggested to bind to a site that is vicinal or allosteric to it, which results in a reduced binding affinity for tubulin. The R-enantiomer of this compound lacks the ability to depolymemrize tubulin (>10 µM) and is included as a negative control.
FormOff-white solid
Formulation1 set contains 2 mg (S)-Dosabulin (+) (Cat. No. 5.30543.0001) and 2 mg (R)-Dosabulin Negative Control (-) (Cat. No. 5.30544.0001).
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₂O₂S
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesIbbeson, B. M., et al. 2014. Nature Comm. 5, 3155.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools