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FCMAB257P Milli-Mark™Anti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5

FCMAB257P
100 tests  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMPhycoerythrinMonoclonal Antibody
      Description
      Catalogue NumberFCMAB257P
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™Anti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5
      Alternate Names
      • GFAP
      Background InformationGlial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
      References
      Product Information
      FormatPhycoerythrin
      Control
      • U251 cells
      PresentationPurified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationMilli-MarkAnti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5 detects level of Glial Fibrillary Acidic Protein & has been published & validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenPurified glial filament (Debus, E., 1983).
      CloneGA5
      HostMouse
      SpecificityAntibody recognizes Human Glial Fibrillary Acidic Protein.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined
      Gene Symbol
      • GFAP
      • FLJ45472
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

      SIZE: 432 amino acids; 49880 Da

      SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.

      SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.

      DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.

      SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family. ...
      Molecular Weight50 kDa Calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using U251 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Milli-Mark™Anti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5 SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark™Anti-Glial Fibrillary Acidic Protein-PE Antibody, clone GA5 Certificates of Analysis

      TitleLot Number
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 2115666 2115666
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 1958311 1958311
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 1983987 1983987
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 1993784 1993784
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 2045868 2045868
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 2090948 2090948
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 2151863 2151863
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 2201488 2201488
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - 2228131 2228131
      Milli-MarkAnti-Glial Fibrillary Acidic Protein-PE, clone GA5 - NG1948286 NG1948286

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies