531976 MPS1 Inhibitor III, AZ3146 - Calbiochem

531976
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₄H₃₂N₆O₃

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable purinone derivative that acts as a highly potent and selective inhibitor of monopolar spindle 1 kinase (MPS1; IC50 = ~35 nM). Inhibits the phosphorylation of full-length immunoprecipitated human MPS1 and exhibits minimal activity against a panel of 49 other protein kinases. Has much reduced activity against FAK, JNK1, JNK2, and KIT and does not affect the activity of mitotic-specific phosphoforms of Aurora B and BubR1. Induces a significant reduction in time to complete mitosis (from 90 min to 32 min) and causes abnormal mitosis where over 50% of cells enter anaphase without aligning their chromosomes.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531976
      Brand Family Calbiochem®
      SynonymsAZ 3146, AZ-3146, Monopolar Spindle 1 Kinase Inhibitor, AZ3146
      References
      ReferencesHewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.
      Product Information
      FormPurple powder
      Hill FormulaC₂₄H₃₂N₆O₃
      Chemical formulaC₂₄H₃₂N₆O₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMPS1
      Primary Target IC<sub>50</sub>~35 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MPS1 Inhibitor III, AZ3146 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Hewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-December-2014 JSW
      SynonymsAZ 3146, AZ-3146, Monopolar Spindle 1 Kinase Inhibitor, AZ3146
      DescriptionA cell permeable purinone derivative that acts as a highly potent and selective inhibitor of monopolar spindle 1 kinase (MPS1; IC50 = ~35 nM). Inhibits the phosphorylation of full-length immunoprecipitated human MPS1 and exhibits minimal activity against a panel of 49 other protein kinases. Has much reduced activity against FAK, JNK1, JNK2, and KIT and does not affect the activity of mitotic-specific phosphoforms of Aurora B and BubR1. Induces a significant reduction in time to complete mitosis (from 90 min to 32 min) and causes abnormal mitosis where over 50% of cells enter anaphase without aligning their chromosomes.
      FormPurple powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₃₂N₆O₃
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.