435801 Sigma-AldrichLicofelone, Potassium Salt, Monohydrate - CAS 156897-06-2 - Calbiochem
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Overview
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Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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435801-25MG |
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Glass bottle | 25 mg |
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Description | |
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Overview | A cell-permeable, orally active arylpyrrolizine carboxylate that is structurally and pharmacologically similar to, but less potent than, MK-886 (Cat. No. 475889). Effectively suppresses cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2 (IC50 = 0.8, 6, and >30 µM, respectively), and inhibits cellular 5-LO (5-Lypoxygenase; Cat. No. 437996) pathway activation (IC50 = 0.18 to 3.6 µM against ionophore-stimulated LB4 production from bovine and human PMNL, respectively) by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity. Unlike NSAIDs that target only COX pathway, Licofelone does not cause gastrointestinal damages when applied in vivo. |
Catalogue Number | 435801 |
Brand Family | Calbiochem® |
Synonyms | FLAP Inhibitor II, mPGES-1 Inhibitor II, 2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl, 2,3-dihydro-1H-pyrrolizine-5-yl)-acetic acid, ML3000, ML-3000, COX-1 Inhibitor V |
Product Information | |
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CAS number | 156897-06-2 |
Form | White powder |
Hill Formula | C₂₃H₂₁ClKNO₂•H₂O |
Chemical formula | C₂₃H₂₁ClKNO₂•H₂O |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | 5-LOX |
Primary Target IC<sub>50</sub> | 0.21 µ |
Secondary target | COX |
Purity | ≥99% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Transport Information |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalog Number | GTIN |
435801-25MG | 04055977210323 |
Documentation
References
Reference overview |
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Laufer, S. A., et al. 1994. Arzneimittelforschung. 44, 629. Laufer, S., et al. 1994. Arzneimittelforschung. 45, 27. Wallace, J. L., et al. 1994. Eur J Pharmacol. 271, 525. Alvaro-Garcia, J. M., et al. 2004. Rheumatology. 43 Supple1, i21. Koeberle, A., et al. 2008. J Pharmacol Exp Ther. 326, 975. Fischer, L., et al. 2007. Br J Pharmacol. 152, 471. Laufer, S. A., et al. 1994. J Med Chem. 37, 1894. Vidal, C., et al. 2007. J Pharmacol Exp Ther. 320, 108. Liedtke, A. J., et al. 2009. J Med Chem. 52, 4968. Bias, P., et al. 2004. Am J Gastroenterol. 99, 611. |
Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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