531068 Lenaldekar (LDK) - Calbiochem

531068
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₈H₁₄N₄

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.31068.0001
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA quinolinyl hydrazone derived compound that specifically blocks the proliferation of T cells in a dose-dependent manner (IC50 = 3 µM in CD3+, CD4+, and CD8+ cells) without affecting other cell types. Its anti-proliferative effects are non-cytolytic in nature. Induces cell cycle delay at G2/M phase. Selectively induces apoptosis in human leukemic blasts and is shown to be active against all acute lymphoblastic leukemia cell lines (IC50 = 1 -2 µM) and also displays in vivo activity in a zebrafish T-ALL model. Reduces the growth of human T-ALL in murine xenograft models (16 mg/kg, i,p, b.i.d). Also shown to specifically block myelin specific T cell responses and reduce inflammation and demyelination in experimental autoimmune encephalomyelitis, possibly via its interactions with insulin-like growth factor-1 receptor. Diminishes the phosphorylation of T308 and S473 on Akt, however, its action is believed to be upstream of PI-3K/Akt. Does not affect the activity of over 450 other kinases in any significant manner. Exhibits a plasma t1/2 = 2 h.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531068
      Brand Family Calbiochem®
      SynonymsT Cell Proliferation Inhibitor, LDK
      References
      ReferencesCusick, M.F., et al. 1999. PNAS. 96, 12192.
      Ridges, S, et al. 2012. Blood. 119, 5621.
      Product Information
      FormYellow powder
      Hill FormulaC₁₈H₁₄N₄
      Chemical formulaC₁₈H₁₄N₄
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>3 µM to block proliferation of T lymphocytes
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Lenaldekar (LDK) - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Cusick, M.F., et al. 1999. PNAS. 96, 12192.
      Ridges, S, et al. 2012. Blood. 119, 5621.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-August-2014 JSW
      SynonymsT Cell Proliferation Inhibitor, LDK
      DescriptionA quinolinyl hydrazone derived compound that specifically blocks the proliferation of T cells in a dose-dependent manner (IC50 = 3 µM in CD3+, CD4+, and CD8+ cells) without affecting other cell types. Its anti-proliferative effects are non-cytolytic in nature. Induces cell cycle delay at G2/M phase. Selectively induces apoptosis in human leukemic blasts and is shown to be active against all acute lymphoblastic leukemia cell lines (IC50 = 1 -2 µM) and also displays in vivo activity in a zebrafish T-ALL model. Reduces the growth of human T-ALL in murine xenograft models (16 mg/kg, i,p, b.i.d). Also shown to specifically block myelin specific T cell responses and reduce inflammation and demyelination in experimental autoimmune encephalomyelitis, possibly via its interactions with insulin-like growth factor-1 receptor. Diminishes the phosphorylation of T308 and S473 on Akt, however, its action is believed to be upstream of PI-3K/Akt. Does not affect the activity of over 450 other kinases in any significant manner. Exhibits a plasma t1/2 = 2 h.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₄N₄
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCusick, M.F., et al. 1999. PNAS. 96, 12192.
      Ridges, S, et al. 2012. Blood. 119, 5621.